| 摘要 |
PURPOSE: Provided is a pharmaceutical composition comprising 2-chloro-5-£5-(2-imino-4-oxo-thiazolidin-5-yl idenemethyl)-furan-2-yl|-benzoic acid derivatives of the formula(1) to inhibit the activity of protein tyrosine phosphatase 1B(PTP 1B). It effectively inhibits the activity of PTP 1B and is thus used for the prevention and treatment of obesity or diabetes. CONSTITUTION: A pharmaceutical composition for the inhibit the activity of protein tyrosine phosphatase 1B(PTP 1B) is characterized by comprising 2-chloro-5-£5-(2-imino-4-oxo-thiazolidin-5-yl idenemethyl)-furan-2-yl|-benzoic acid derivatives of the formula(1), their pharmaceutically acceptable salt, hydrate, solvate or isomer. In the formula, R1 is an aromatic group substituted or unsubstituted with at least one of halogen, alkyloxy, alkyl, amino, alkyl amino, carboxylic acid or amide; a nitrogen, sulfur or oxygen-containing aromatic group; or an aromatic group substituted or unsubstituted C1-C6 alkyl, and R2 is hydrogen; an aromatic group substituted or unsubstituted with at least one of halogen, alkyloxy, alkyl, amino, alkylamino, carboxylic acid or amide; a nitrogen, sulfur or oxygen-containing aromatic group; or an aromatic group substituted or unsubstituted C1-C6 alkyl, and R2 is hydrogen.
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