| 摘要 |
FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing cyclic thioamides that can be used for preparing aralkyl- and aralkylidene-heterocyclic lactams and imides that, in turn, are selective agonists and antagonists of serotonin-1 receptors (5-HT1). Invention describes method for preparing cyclic thioamides of the formula (I): wherein b = 0, 1, 2 or 3; Y represents oxygen, sulfur atom, NH or N-acetyl and each R3 is taken independently among group consisting of halogen atom, cyano-group, (C1-C6)-alkyl, (C1-C6)-alkoxy-group and trifluoromethyl. Method involves interaction of compound of the formula (II): with dehydrating agent. Invention describes also intermediate compounds used in preparing final products. Proposed method provides carrying out aminolysis of carboxylc acid without necessary conversion of acid to ester or chloroanhydride. EFFECT: improved preparing method, valuable properties of compounds. 12 cl, 1 ex
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