发明名称 |
CHEMICAL SYNTHESIS OF REAGENTS FOR PEPTIDE COUPLING |
摘要 |
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The inventi on provides phosphineborane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
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申请公布号 |
CA2489186(A1) |
申请公布日期 |
2003.12.18 |
申请号 |
CA20032489186 |
申请日期 |
2003.06.06 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
HE, YI;KIESSLING, LAURA L.;NILSSON, BRADLEY L.;RAINES, RONALD T.;HINKLIN, ROLAND J.;SOELLNER, MATTHEW B. |
分类号 |
C07K2/00;C07F5/02;C07F9/02;C07F9/50;C07F19/00;C07K1/00;C07K5/06;C07K5/062;C07K14/00;(IPC1-7):C07F5/02;C07K17/00 |
主分类号 |
C07K2/00 |
代理机构 |
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地址 |
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