The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-ß phosphorylation of I:B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-:B in which diseases excessive activation of NF-:B is implicated.
申请公布号
WO03104218(A1)
申请公布日期
2003.12.18
申请号
WO2003US17385
申请日期
2003.05.29
申请人
SMITHKLINE BEECHAM CORPORATION;CALLAHAN, JAMES, F.;LI, YUE, H.