| 发明名称 |
NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) |
| 摘要 |
Where Y, R1-R8 and R101-R108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy. |
| 申请公布号 |
WO03104178(A1) |
申请公布日期 |
2003.12.18 |
| 申请号 |
WO2003AU00716 |
申请日期 |
2003.06.06 |
| 申请人 |
CORTICAL PTY LTD;MORAND, ERIC, FRANCIS;ISKANDER, MAGDY, NAGUIB |
发明人 |
MORAND, ERIC, FRANCIS;ISKANDER, MAGDY, NAGUIB |
| 分类号 |
A61K31/075;A61K31/12;A61K31/185;A61K31/192;A61K31/205;A61K31/216;A61K31/255;A61K31/277;A61K31/357;A61K31/4184;A61K31/585;A61P25/00;A61P29/00;A61P31/00;A61P35/00;A61P37/00;A61P43/00;C07C43/205;C07C43/225;C07C43/23;C07C45/00;C07C45/46;C07C49/84;C07C57/50;C07C59/58;C07C65/24;C07C65/28;C07C69/76;C07C69/94;C07C205/59;C07C211/57;C07C215/50;C07C219/22;C07C229/70;C07C255/37;C07C309/47;C07C309/60;C07C309/75;C07C323/43;C07C333/04;C07D235/26;C07D307/83;C07D319/18;C07D319/22;C07D403/12;C07H13/10;(IPC1-7):C07C43/205 |
主分类号 |
A61K31/075 |
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