| 摘要 |
<p>The present invention relates to the identification of polynucleotide sequences encoding polypeptides of Alloiococcus otitidis that are essential for the growth and survival of the bacteria. In particular, the invention relates to polypeptides encoded by the Alloiococcus otitidis open reading frames (ORFs), and to their use in pharmaceutical compositions, therapeutics, diagnostics and the like. The present invention also relates to methods for identifying pharmaceutical compounds that inhibit the activity of the polypeptides that are essential for the growth of Alloiococcus otitidis, to pharmaceutical compositions containing these compounds and to their use in treatment and amelioration of diseases caused by Alloiococcus otitidis</p> |
