摘要 |
<p>The invention relates to a process for deuteration of inert alkanes with activated palladium-carbon, specifically, a process for deuterating a compound having either a methyl group or an alkylene group having two or more carbon atoms in a state directly bonded to an optionally substituted aromatic ring through replacement of one or more hydrogen atoms of the methyl group or one or more of the benzylic and other hydrogen atoms of the alkylene group by deuterium, characterized in that the above compound is subjected to refluxing in a closed system in the presence of activated palladium-carbon in a state dissolved in a deuterated solvent.</p> |