发明名称 |
Method and compositions for stimulation of an immune response to CD20 using a xenogeneic CD20 antigen |
摘要 |
Tolerance of the immune system for endogenous CD20 can be overcome and an immune response stimulated by administration of xenogeneic or xenoexpressed CD20 antigen. For example, mouse CD20, or antigenically-effective portions thereof, can be used to stimulate an immune response to the corresponding differentiation antigen in a human subject. Administration of xenogeneic antigens in accordance with the invention results in an effective immunity against CD20 expressed by the cancer in the treated individual, thus providing a therapeutic approach to the treatment of lymphomas and leukemia expressing CD20.
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申请公布号 |
US2003228326(A1) |
申请公布日期 |
2003.12.11 |
申请号 |
US20020285874 |
申请日期 |
2002.10.31 |
申请人 |
PALOMBA MARIA LIA;HOUGHTON ALAN;WOLCHOK JEDD;SCHEINBERG DAVID A.;ROBERTS WENDY K. |
发明人 |
PALOMBA MARIA LIA;HOUGHTON ALAN;WOLCHOK JEDD;SCHEINBERG DAVID A.;ROBERTS WENDY K. |
分类号 |
A61K39/00;C07K14/705;(IPC1-7):A61K38/19;A61K9/127 |
主分类号 |
A61K39/00 |
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