METHODS AND COMPOSITIONS FOR RADIOIMMUNOTHERAPY OF BRAIN AND CNS TUMORS

摘要

A method for treating a brain tumor by administering to a patient (i) a multispecific antibody comprising at least one targeting arm that binds to a brain cancer antigen and at least one capture arm that binds to a radionuclide carrier; (ii) a therapeutic radionuclide carrier to which is bound a therapeutic radionuclide, wherein the multispecific antibody, radionuclide carrier and therapeutic radionuclide are administered in a substantially equimolar ratio.