发明名称 |
Inhibition of gene transcription by polyamide DNA-binding ligands |
摘要 |
The invention provides polyamides suitable for modulating cellular or viral gene expression by binding to an identified target DNA sequence adjacent to the binding site of a minor groove transcription factor protein. The polyamides of the present invention are useful for the treatment of a human infected with a virus such as HIV-1. The polyamides of the present invention are also useful for the treatment of conditions, such as cancers, that result from the expression or over-expression of cellular genes, particularly oncogenes.
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申请公布号 |
US6660255(B1) |
申请公布日期 |
2003.12.09 |
申请号 |
US20000367513 |
申请日期 |
2000.04.25 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
GOTTESFELD JOEL M.;DERVAN PETER B.;MOSIER DONALD E.;BAIRD ELDON E. |
分类号 |
A61K47/48;(IPC1-7):A61K31/785 |
主分类号 |
A61K47/48 |
代理机构 |
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主权项 |
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地址 |
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