发明名称 |
Indole-3-carbinol (I3C) derivatives and methods |
摘要 |
The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula:which inhibits tumor cell growth. Methods of inhibiting targeted cell growth include contacting a target cell with a disclosed compound under conditions whereby the growth the target cell is inhibited, and methods for evaluating the growth inhibitory activity of the compounds include contacting a cell with an effective amount of the compound and measuring the CDK6 expression in the cell, wherein a reduction in CDK6 expression correlates with the growth inhibitory activity of the compound.
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申请公布号 |
US6656963(B2) |
申请公布日期 |
2003.12.02 |
申请号 |
US20020118607 |
申请日期 |
2002.04.08 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
FIRESTONE GARY L.;BJELDANES LEONARD F.;COVER CAROLYN M. |
分类号 |
A61K31/138;A61K31/404;A61K31/407;A61K31/4535;A61K31/56;A61K45/06;(IPC1-7):A61K31/40 |
主分类号 |
A61K31/138 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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