| 摘要 |
The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R<1 >is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR<9>, where R<9 >is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R<10 >and R<11 >are each independently hydrogen, C1-C10alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R<2 >and R<3 >are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl, alkynylaryl or R<2 >and R<3 >together form a cycloalkyl or a cycloaryl moiety; R<4 >is hydrogen or methyl; R<5 >is hydrogen, hydroxyl, oxo, or together with R<6 >and the carbons to which they are attached form a cyclic carbonate; R<6 >is hydrogen, hydroxyl, OR<12 >where R<12 >is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R<5 >and the carbons to which they are attached form a cyclic carbonate; R<7 >is methyl, C3-C10 alkyl, C2-C10alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; R<8 >is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, x is a single or a double bond.
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