<p>The mechanism of hypertension following acute NO synthase blockade is via endothelin-mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a "normal' physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction.</p>
申请公布号
EP0888123(B1)
申请公布日期
2003.11.26
申请号
EP19970906058
申请日期
1997.03.13
申请人
QUEEN'S UNIVERSITY AT KINGSTON
发明人
BANTING, JAMES, D.;HEATON, JEREMY, P., W.;ADAMS, MICHAEL, A.