| 摘要 |
An apparatus and method for fabricating a one or two-dimensional microassays with a matrix of sites favorably disposed for screening substances such as biomolecules, chemicals or cells as described. The method includes drilling a matrix of wells or through-holes in a glass or similar material using a laser. The drilling creates a region favorably disposed towards binding a molecule or cell. A microassay plate includes a substrate and at least one hole in the substrate containing an immobilized reactant bound to an interior surface of the hole. An array of holes having chemically different immobilized reactants is provided. Holes may be drilled using one or more pulses of light of extremely short duration to create a surface in a localized area that preferentially binds to material.
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