发明名称 |
SENSITIZED ONLINE BOLD-MRI IMAGING METHOD |
摘要 |
An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imagin g (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer which, upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption, comprising: (i) generating a BOLD-weighted MR-image of the target region of interest within the patient's body (time t0); (ii) administering said sensitizer to the patient; (iii) irradiating the target region while the patient is subjected to continuous MR imaging; (iv) generating a sole or a plurality of T2* weighted sequential BOLD MR-images during and/or after irradiation (time t); (v) processing the data generated at time t0 and time t and generating a color-coded difference or ratio map on a pixel by pixel basis; and (vi) analyzing the processed data. The method is preferably appli ed to photodynamic therapy (PDT). |
申请公布号 |
CA2485224(A1) |
申请公布日期 |
2003.11.20 |
申请号 |
CA20032485224 |
申请日期 |
2003.05.08 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
GILEAD, ASSAF;GROSS, SHIMON;SCHERZ, AVIGDOR;NEEMAN, MICHAL;SALOMON, YORAM |
分类号 |
A61N5/06;A61B;A61B5/055;G01R33/48;(IPC1-7):A61B5/055 |
主分类号 |
A61N5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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