| 摘要 |
Method for inhibiting expression of a target gene (A) in a cell by introducing at least one oligoribonucleotide (O1) that has a double-stranded (ds) structure consisting of at most 49 sequential nucleotide (nt) pairs, with at least part of one strand (S1) complementary with (A), and has, at least one end, a single-stranded (ss) segment of 1-4 nt. Independent claims are also included for: (a) O1 that target any of 140 gene sequences defined in the specification; and (b) kit comprising at least one O1, at least one other oligoribonucleotide (O2) with same size and structure as O1 but not necessarily having an ss-end, and/or interferon. ACTIVITY : Cytostatic; virucide; protozoacide; antibacterial. No biological data given. MECHANISM OF ACTION : Antisense inhibition of gene expression. No biological data given. |
