| 摘要 |
Compounds of the general formula are described:whereinR<1 >is hydrogen or halogen;R<2 >is hydrogen, halogen, lower alkyl or lower alkoxy;R<3 >is halogen, trifluoromethyl, lower alkoxy or lower alkyl;R<4>/R<4'>are each independently hydrogen or lower alkyl;R<5 >is lower alkyl, lower alkoxy, amino, hydroxy, hydroxy-lower alkyl, -(CH2)n-piperazinyl, optionally substituted by lower alkyl, -(CH2)n-morpholinyl, -(CH2)n+1-imidazolyl, -O-(CH2)n+1-morpholinyl, -O-(CH2)n+1-piperidinyl, lower alkyl-sulfanyl, lower alkyl-sulfonyl, benzylamino, -NH-(CH2)n+1N(R<4''>)2, -(CH2)n-NH-(CH2)n+1N(R<4''>)2, -(CH2)n+1N(R<4''>)2, or -O-(CH2)n+1N(R<4''>)2, wherein R<4''> is hydrogen or lower alkyl;R<6 >is hydrogen;R<2 >and R<6 >or R<1 >and R<6 >may together be -CH=CH-CH=CH-, wherein R<2 >and R<6 >or R<1 >and R<6>, respectively, together with the two carbon ring atoms to which they are attached form a fused ring, with the proviso that n for R<1 >is 1;n is independently 0-2; andX is -C(O)N(R<4''>)- or -N(R<4''>)C(O)-;and pharmaceutically acceptable acid addition salts thereof. |
