摘要 |
This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specificall y, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds .
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申请人 |
EXELIXIS INC. |
发明人 |
BUHR, CHRIS A.;BAIK, TAE-GON;PETO, CSABA J.;RICE, KENNETH D.;IBRAHIM, MOHAMED ABDULKADER;MA, SUNGHOON;TESFAI, ZEROM;SCHNEPP, KEVIN LUKE;MANN, LARY WAYNE;TAKEUCHI, CRAIG STACY;TSANG, TSZE H.;NUSS, JOHN M.;CO, ERICK WANG;WANG, LONGCHENG;DUBENKO, LARISA;MANN, GRACE;CHEN, BAILI;ANAND, NEEL KUMAR;FORSYTH, THIMOTHY PATRICK;DALRYMPLE, LISA ESTHER;KENNEDY, ABIGAIL R.;HUYNH, TAI PHAT;SHI, XIAN;LEAHY, JAMES WILLIAM;CHEN, JEFF;EPSHTEYN, SERGEY |