QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR

摘要

It is intended to provide compounds inhibiting the autophosphorylation of macrophage colony stimulating factor receptor. Thus, compounds of the following general formula (I), salts thereof and solvates of the same are provided. (I) wherein X represents CH or N; Z represents O or S; R1, R2 and R3 represent each H, optionally substituted alkoxy, etc.; R4 represents H; R5, R6, R7 and R8 represent each H, halogeno, alkyl, alkoxy, trifluoromethyl, etc.; R9 and R10 represent each H, alkyl, etc.; and one of R11 and R12 represents H while the other represents alkyl and R13 represents an optionally substituted carbon ring, a heterocycle, etc., or R11 represents H and R12 and R13 together form a bicyclic carbon ring.