| 发明名称 |
MUTATIONS CAUSED BY ACTIVATION-INDUCED CYTIDINE DEAMINASE |
| 摘要 |
Methods for causing mutations in genes expressed in eukaryotic cells are provided. The methods involve expressing an activation-induced cytidine deaminase (AID) in the cells. The mutated genes can be any gene that is operably linked to a promoter, where the gene is within about 2 kilobases of the promoter. Examples include antibody genes. Also provided are cells expressing AID. The cells can be from any eukaryote, and include hybridoma cells and myeloma fusion partners. |
| 申请公布号 |
WO03061363(A3) |
申请公布日期 |
2003.11.13 |
| 申请号 |
WO2003US01149 |
申请日期 |
2003.01.15 |
| 申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY;MARTIN, ALBERTO;SCHARFF, MATTHEW, D. |
发明人 |
MARTIN, ALBERTO;SCHARFF, MATTHEW, D. |
| 分类号 |
C12N5/10;C12N5/12;C12N5/22;C12N5/26;C12N15/10;C12N15/63;C12N15/85;C12P21/02;C12Q1/02;C12Q1/68 |
主分类号 |
C12N5/10 |
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