发明名称 Process of obtainment of racemic cetamine enantiomers; process of obtainment of pharmaceutically acceptable salts from racemic cetamine enantiomes and use of pharmaceutically acceptable salts obtained by means of said mentioned process
摘要 The present invention describes a new process for obtainment of the cetamine enantiomers, from the racemic cetamine resolutions with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers. The resolution agent is employed in special concentration conditions, which provides stability, reproducibility and high enantiomeric purity to the precipitated diasteromer salt, making feasible the industrial production of the S-cetamine and its pharmaceutically acceptable salts.
申请公布号 US2003212143(A1) 申请公布日期 2003.11.13
申请号 US20020297815 申请日期 2002.12.10
申请人 TORRES/RUSSO VALTER FREIRE;SOUZA/RUSSO ELISA MANNOCHIO DE 发明人 TORRES/RUSSO VALTER FREIRE;SOUZA/RUSSO ELISA MANNOCHIO DE
分类号 A61P23/00;A61P25/04;C07B57/00;C07C221/00;C07C225/12;(IPC1-7):A61K31/137;C07C225/18 主分类号 A61P23/00
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