发明名称 |
METHOD OF PREVENTING T-CELL MEDIATED RESPONSES BY MAP PROTEINS |
摘要 |
A method of immunomodulating the T cell response in Staphylococcal bacteria is provided wherein an effective amount of the Map protein from Staphylococcus aureus is administered to a host to prevent or suppress the T cell response. The present method may be utilized with either the Map protein or an effective subdomain of fragment thereof such as the Map10 or Map19 protein. The present invention is advantageous in that suppression or prevention of the T cell response in a host can prevent or ameliorate a wide variety of the pathogenic conditions such as T cell lymphoproliferative disease and toxic shock syndrome wherein the overstimulation of T cell needs to be suppressed or modulated.
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申请公布号 |
WO02077010(A8) |
申请公布日期 |
2003.11.13 |
申请号 |
WO2002US00401 |
申请日期 |
2002.01.10 |
申请人 |
THE TEXAS A & M UNIVERSITY SYSTEM |
发明人 |
BROWN, ERIC, N.;LEE, LAWRENCE, Y.;HOOK, MAGNUS |
分类号 |
A61K38/00;C07K14/31;(IPC1-7):A61K39/00;A61K39/02;A61K39/085 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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