发明名称 Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use
摘要 Compounds of formula I,in which R<1>, R<2>, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, for treating thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. Also disclosed are processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
申请公布号 US6645992(B2) 申请公布日期 2003.11.11
申请号 US20010965790 申请日期 2001.10.01
申请人 AVENTIS PHARMA DEUTSCHLAND GMBH 发明人 SCHUDOK MANFRED;KLINGLER OTMAR;NESTLER HANS-PETER;MATTER HANS;SCHREUDER HERMAN
分类号 C07D317/58;A61K31/155;A61K31/167;A61K31/192;A61K31/216;A61K31/225;A61K31/27;A61K31/275;A61K31/343;A61K31/357;A61K31/36;A61K31/433;A61K31/498;A61P7/02;C07C257/18;C07C257/20;C07C315/04;C07C317/32;C07D241/44;C07D285/06;C07D307/79;C07D319/18;(IPC1-7):C07D257/18;C07D237/00 主分类号 C07D317/58
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