发明名称 |
PROCESS FOR 5-[[2(R)-[1(R)-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY]-3(S)-(4-FLUOROPHENYL)-4-MORPHOLINYL]METHYL]-1,2-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE |
摘要 |
The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of psychiatric disorders, inflammatory diseases and emesis. |
申请公布号 |
WO03089429(A1) |
申请公布日期 |
2003.10.30 |
申请号 |
WO2003US11956 |
申请日期 |
2003.04.17 |
申请人 |
MERCK & CO., INC.;MERCK SHARP & DOHME LIMITED;HUFFMAN, MARK;KABA, MAHMOUD, S.;PAYACK, JOSEPH, F.;HANDS, DAVID |
发明人 |
HUFFMAN, MARK;KABA, MAHMOUD, S.;PAYACK, JOSEPH, F.;HANDS, DAVID |
分类号 |
A61K31/5377;A61P1/12;A61P25/18;A61P29/00;A61P43/00;C07D265/32;C07D413/02;C07D413/06;(IPC1-7):C07D413/06 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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