INHIBITION OF II EXPRESSION IN MAMMALIAN CELLS

摘要

The present invention is directed toward composition and methods involving t he inhibition of Ii expression in cells for the purpose of altering antigen presentation pathways. More specifically, disclosed are compositions and methods which relate to MHC Class II molecule presentation of antigenic epitopes which, under normal circumstances, would not be presented in association with MHC Class II molecules. The invention relates to presentati on in cells which normally express MHC Class II molecules, as well as cells whi ch can be induced to express MHC Class II molecules.