| 摘要 |
<p>A process for producing a 2-oxobicycloÄ3.1.0Ühex-3-ene-6-carboxylic acid derivative represented by a formula: <CHEM> (wherein R<1> represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkyl C1-6 alkyl group, a C1-6 alkyl group substituted with a substituted or unsubstituted phenyl group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 hydroxyalkyl group, a C1-6 alkylthio C1-6 alkyl group, a C1-6 mercaptoalkyl group, or a substituted or unsubstituted phenyl group) characterized by reacting a 4-hydroxy-2-oxobicycloÄ3.1.0Ühexane-6-carboxylic acid derivative represented by a formula: <CHEM> (wherein R<1> has the same meaning as described above, and R<2> represents a hydrogen atom or a protective group of a hydroxyl group) in the presence of an acid or a base. <??>A process for producing the compounds which are useful for efficient syntheses of 2-amino-3-fluorobicycloÄ3.1.0Ühexane-2,6-dicarboxylic acids is provided.</p> |
