发明名称 |
c-Jun PHOSPHORYLATION INHIBITORS |
摘要 |
BMAL1, BPL1, KIAA1491 complete (SEQ ID NO:1) and KIAA0596CT (SEQ ID NO:2) having a function of interacting with c-Jun N-terminal kinase 3 are found out. Using them and peptides originating therein, drugs and medicinal compositions to be used in inhibiting the phosphorylation of c-Jun, inhibiting the functions (for example, transcription activation) of c-Jun, inhibiting apoptosis (for example, apoptosis in nerve cells) and preventing and/or treating neurodegenerative diseases (for example, polyglutamine disease and Alzheimer's disease) and a method therefor are provided.
|
申请公布号 |
WO03086462(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
WO2003JP04120 |
申请日期 |
2003.03.31 |
申请人 |
CELESTAR LEXICO-SCIENCES,INC.;DAIICHI PHARMACEUTICAL CO.,LTD.;DOI, HIROFUMI;WADA, NAOYA;NAKAJIMA, HIROTO |
发明人 |
DOI, HIROFUMI;WADA, NAOYA;NAKAJIMA, HIROTO |
分类号 |
A61K38/17;A61P25/00;(IPC1-7):A61K45/00 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|