| 发明名称 |
HETEROARYL SUBSTITUTED TRIAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 |
| 摘要 |
Triazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl which are metabotropic glutamate receptor - subtype 5 ("mGluR5") modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal and other diseases. |
| 申请公布号 |
WO03051315(A3) |
申请公布日期 |
2003.10.23 |
| 申请号 |
WO2002US41720 |
申请日期 |
2002.12.13 |
| 申请人 |
MERCK & CO., INC.;COSFORD, NICHOLAS, D., P.;TEHRANI, LIDA, R.;ROPPE, JEFFREY, R.;SMITH, NICHOLAS, D.;PRASIT, PETPIBOON |
发明人 |
COSFORD, NICHOLAS, D., P.;TEHRANI, LIDA, R.;ROPPE, JEFFREY, R.;SMITH, NICHOLAS, D.;PRASIT, PETPIBOON |
| 分类号 |
A61K31/135;A61K31/145;A61K31/185;A61K31/19;A61K31/195;A61K31/4439;A61K31/485;A61K31/506;A61K31/5513;A61K45/00;A61K45/06;A61P3/04;A61P3/12;A61P3/14;A61P21/00;A61P25/00;A61P25/04;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P29/00;C07D401/04;C07D401/14 |
主分类号 |
A61K31/135 |
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