NON-HUMAN TRANSGENIC MAMMALS CARRYING GERMILE MUTATIONS IN BOTH THE P53 ANDFOS GENES AND THEIR USE AS A DISEASE MODEL

摘要

A non-human mammal that carries germline mutations in both the p53 and the Fos genes, methods for producing it and cell lines derived therefrom. The p53/Fos double knockout animal, in particular a mouse, is useful as a rhabdomyosarcoma disease model.