Process for the preparation of quinolylpropenal

摘要

3-[2-Cyclopropyl-4-(4-fluorophenyl)-3 quinolyl]prop-2-enal is prepared in a high yield by reducing 3-[2-cyclo-propyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile with Raney nickel either in the presence of formic acid and 0.25 to 1 part by volume of water per part by volume of formic acid or in the presence of both an amine salt of formic acid and an organic acid.