DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN G PROTEIN-COUPLED ORPHAN RECEPTOR 21 (GPR21)

摘要

The invention provides a human GPR21 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, COPD, asthma, genito-urological disorders and inflammation diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, COPD, asthma, genito-urological disorders and inflammation diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR21 as well as pharmaceutical compositions comprising such compounds.