FUSED BICYCLIC PYRIMIDINE DERIVATIVES

摘要

It is intended to provide novel fused bicyclic pyrimidine derivatives represented by the following general formula (1) which have antagonism to tachykinin receptors, in particular, NK1 receptor antagonism. Namely, fused bicyclic pyrimidine derivatives represented by the following general formula (1) or salts thereof: (1) wherein the rings A and B represent each a benzene ring optionally having 1 to 3 substituents (wherein two adjacent substituent s may be bonded to each other to form a ring); the ring C represents a nitroge n- containing ring; R represents hydrogen, C1-6 alkyl, C1-6 alkylcarbonyl or C1 -6 alkylsulfonyl; m is 1 or 2; and n is 2 or 3.