ANTIBODY DISULFIDE ISOMERS, USE THEREOF, AND METHODS OF ANALYZING SAME
摘要
The present invention relates to disulfide isomers of an antibody having specificity for antigenic determinants of human tumor necrosis factor alpha (TNFalpha). The present invention also relates to compositions comprising the isomers and therapeutic uses of the antibody. The present invention also relates to analytical methods of detecting the TNFalpha antibody disulfide isomers and oxidated methionyl forms of the TNFalpha antibodies.
申请公布号
WO03080674(A1)
申请公布日期
2003.10.02
申请号
WO2003US08608
申请日期
2003.03.20
申请人
PHARMACIA CORPORATION;MOZIER, NED, M.;DUFIELD, ROBERT, L.;MO, JIANMING;BILD, GARY, S.
发明人
MOZIER, NED, M.;DUFIELD, ROBERT, L.;MO, JIANMING;BILD, GARY, S.