A process for the synthesis of pergolide (Formula(I)) (D-6-n-propyl-8betamethylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from the yield and safety standpoint. Moreover, pergolide thereby obtained is highly pure and can be conveniently transformed into pergolide mesylate.
申请公布号
WO03078432(A2)
申请公布日期
2003.09.25
申请号
WO2003EP02423
申请日期
2003.03.10
申请人
ANTIBIOTICOS S.P.A.;CABRI, WALTER;PAISSONI, PAOLO;ROLETTO, JACOPO;FONTE, PIERA;OLMO, SARA
发明人
CABRI, WALTER;PAISSONI, PAOLO;ROLETTO, JACOPO;FONTE, PIERA;OLMO, SARA