发明名称 |
Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer |
摘要 |
The present invention relates to a process of preparing a sustained release micelle by copolymerizing a biodegradable polyester hydrophobic polymer and a hydrophilic polyethylene glycol (PEG) to obtain a block copolymer, reacting the block copolymer with a linker to the hydroxyl group of the block copolymer and conjugating the linker-bound block copolymer to a drug to obtain a micelle monomer, and dispersing the micelle monomer an aqueous solution. The drug-micelle conjugate of the present invention has practical application in anticancer therapy.
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申请公布号 |
US6623729(B2) |
申请公布日期 |
2003.09.23 |
申请号 |
US20010902549 |
申请日期 |
2001.07.09 |
申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
PARK TAE GWAN;YOO HYUK SANG |
分类号 |
A61K31/282;A61K31/337;A61K31/513;A61K31/704;(IPC1-7):A61K47/48;A61K31/74;A61K31/785;A61K9/14 |
主分类号 |
A61K31/282 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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