PEPTIDES FOR FACILITATING COMPOSITE RECEPTOR EXPRESSION AND TRANSLOCATION OF MACROMOLECULES
摘要
The invention relates to compositions and methods for expressing a composite receptor on the cell surface. The composite receptor can be integrated into a cell membrane via a fusion peptide which includes a cell penetrating domain linked to a transmembrane domain. In a preferred embodiment, the composite receptor further comprises a ligand binding domain. In yet another embodiment the invention relates to compositions and methods for translocating a nucleic acid or other molecule across the cell membrane into the cell. In a preferred embodiment, the nucleic acid or other molecule is linked to a fusion peptide comprising an adapter domain which is linked to a cell penetrating domain.
申请公布号
WO02062823(A3)
申请公布日期
2003.09.04
申请号
WO2002US02837
申请日期
2002.02.01
申请人
YALE UNIVERSITY;RABINOVICH, PETER;BRAY-WARD, PATRICIA;WARD, DAVID, C.
发明人
RABINOVICH, PETER;BRAY-WARD, PATRICIA;WARD, DAVID, C.