发明名称 |
Compositions and methods related to TIM-3, a Th1-specific cell surface molecule |
摘要 |
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease. |
申请公布号 |
AU2003303082(A1) |
申请公布日期 |
2003.08.28 |
申请号 |
AU20030303082 |
申请日期 |
2003.01.30 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
LAURENT MONNEY;VIJAY K KUCHROO;HANSPETER WALDNER;GORDON J FREEMAN;JASON L GAGLIA;EDWARD A GREEFIELD |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61P31/04;A61P35/00;A61P43/00;C07K16/28;C12N5/06;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|