发明名称 |
INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS |
摘要 |
Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insul in- like growth factor receptors, and which selectively bind the peptides of thi s invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.</SD OAB>
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申请公布号 |
CA2460055(A1) |
申请公布日期 |
2003.08.28 |
申请号 |
CA20022460055 |
申请日期 |
2002.09.24 |
申请人 |
DGI BIOTECHNOLOGIES;NOVO NORDISK A/S |
发明人 |
GOLDSTEIN, NEIL I.;BRANDT, JAKOB;SCHAFFER, LAUGE;BLUME, ARTHUR J.;OSTERGAARD, SOREN;PILLUTLA, RENUKA;SPETZLER, JANE;BRISSETTE, RENEE |
分类号 |
G01N33/50;A61K38/00;A61K48/00;A61P3/10;A61P43/00;C07K7/06;C07K7/08;C07K14/00;C07K14/62;C07K14/65;C12N5/06;C12N15/09;G01N33/15;(IPC1-7):C07K14/65;C07K7/00;A61K38/04;A61K38/28;A61K38/30;G01N33/566 |
主分类号 |
G01N33/50 |
代理机构 |
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地址 |
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