发明名称 |
METHODS FOR PRODUCING AND IMPROVING THERAPEUTIC POTENCY OF BINDING POLYPEPTIDES |
摘要 |
The invention provides a binding polypeptide, or functional fragment thereof, comprising a kon of at least about 9 x 10<7> M<-1> s<-1> for associating with a ligand and having therapeutic potency. The invention also provides a method of determining the therapeutic potency of a binding polypeptide. The methods consist of (a) contacting a binding polypeptide with a ligand; (b) measuring association rate for binding between the binding polypeptide and the ligand, and (c) comparing the association rate for the binding polypeptide to an association rate for a therapeutic control, the relative association rate for the binding polypeptide compared to the association rate for the therapeutic control indicating that the binding polypeptide wil exhibit a difference in therapeutic potency correlative with the difference between the association rates. |
申请公布号 |
WO0236615(A3) |
申请公布日期 |
2003.08.21 |
申请号 |
WO2001US46248 |
申请日期 |
2001.10.30 |
申请人 |
APPLIED MOLECULAR EVOLUTION, INC.;HUSE, WILLIAM, D. |
发明人 |
HUSE, WILLIAM, D. |
分类号 |
A61K38/00;A61K38/22;A61K38/28;A61K38/43;A61K38/44;A61K38/45;A61K38/46;A61K39/395;C07K1/00;C07K14/00;C07K16/00;C12N9/18;G01N33/557 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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