5-HT2B RECEPTOR ANTAGONISTS

摘要

The present invention concerns compounds of formula I: wherein R1 is selected from the group consisting of H, and optionally substituted C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl, and phenyl-C 1-4 alkylR2 and R3 are either: i independently selected from H, R, R', SO2R, C=OR, CH2nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C 1-4 alkyl group, and R' is an optionally substituted phenyl- C 1-4 alkyl group, or ii together with the nitrogen atom to which they are attached, form an optionally substituted C 5-7 heterocyclic group R4 is an optionally substituted C 9-14 aryl group their use as pharmaceuticals, in particular for treating conditions alleviated by antagonism of a 5-HT 2B receptor.