Methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof

摘要

The present invention provides methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives according to the following general reaction scheme: The invention also provides intermediates useful in making such 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives as well as methods for making such intermediates.