PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION

摘要

The present invention relates to compounds of the formula (X) which are useful in the synthesis of pyrazolopyrimidinone compounds: wherein: R<13> is C1 to C4 alkyl optionally substituted with one or two substituents selected from OH, C1 to C4 alkoxy, benzyloxy, NR<5>R<6>, phenyl, furanyl and pyridinyl; C3 to C6 cycloalkyl; 1-(C1 to C4 alkyl)piperidinyl; tetrahydrofuranyl or tetrahydropyranyl; R<4> is SO2NR<7>R<8>; R<5> and R<6> are each independently selected from H and C1 to C4 alkyl, or, together with the nitrogen atom to which they are attached, form a pyrrolidinyl, piperidinyl or morpholinyl group; R<7> and R<8>, together with the nitrogen atom to which they are attached, form a 4-R<10> piperazinyl group optionally substituted with one or two C1 to C4 alkyl groups and optionally in the form of its 4-N-oxide; R<10> is H; C1 to C4 alkyl optionally substituted with one or two substituents selected from OH, NR<5>R<6>, CONR<5>R<6>, phenyl optionally substituted with C1 to C4 alkoxy, benzodioxolyl and benzodioxanyl; C3 to C6 alkenyl; pyridinyl or pyrimidinyl; or a salt of such compound, or an acid chloride derivative of such compound.