PRODUCTION OF EPI-HNE-4 COMPRISING REDUCTION OF IMPROPERLY PROCESSED FORM

摘要

The present invention concerns novel nucleotide sequences, gene constructs, expression vectors and micro-organisms for secreting a protein, in particular an EPI-hNE protein such as EPI-hNE-4, with very low levels, or undetectable levels, of an improperly processed form of said protein which contains 9 extra amino-terminal amino acids as compared to the correctly processed form.