| 发明名称 |
Polynucleotide molecules encoding neospora proteins |
| 摘要 |
The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum, as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1IMAGI promoter of N. caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.
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| 申请公布号 |
US6600027(B1) |
申请公布日期 |
2003.07.29 |
| 申请号 |
US19990276438 |
申请日期 |
1999.03.25 |
| 申请人 |
PFIZER, INC.;PFIZER PRODUCTS, INC. |
发明人 |
KRISHNAN B. RAJENDRA;MADURA REBECCA;YODER CHRISTINE;DURTSCHI BECKY;BRAKE DAVID A. |
| 分类号 |
C12N15/02;A61K31/00;A61K35/12;A61K38/00;A61K39/00;A61K39/002;A61K39/02;A61K39/07;A61K39/08;A61K39/085;A61K39/09;A61K39/106;A61K39/108;A61K39/112;A61K39/12;A61K39/145;A61K39/15;A61K39/205;A61K39/215;A61K39/245;A61K39/295;A61K39/39;A61K48/00;A61P15/06;A61P25/00;A61P31/00;A61P31/04;A61P31/12;A61P33/00;C07K14/44;C07K16/18;C07K16/20;C12N1/11;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/30;C12P21/02;C12P21/08;C12R1/90;(IPC1-7):C07H21/02;C07H21/04;C12P21/06;C12N1/20;C12N15/00 |
主分类号 |
C12N15/02 |
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