The present invention provides antibody targeting compounds in which the specificity of the antibody has been reprogrammed by covalently or noncovalently linking a targeting agent to the combining site of an antibody. By this approach, the covalently modified antibody takes on the binding specificity of the targeting agent. The compound may have biological activity provided by the targeting agent or by a separate biological agent. Various uses of the invention compounds are provided.
申请公布号
WO03059251(A2)
申请公布日期
2003.07.24
申请号
WO2002US33991
申请日期
2002.10.22
申请人
THE SCRIPPS RESEARCH INSTITUTE;BARBAS, CARLOS, F.;RADER, CHRISTOPH;SINHA, SUBHASH, C.;LERNER, RICHARD
发明人
BARBAS, CARLOS, F.;RADER, CHRISTOPH;SINHA, SUBHASH, C.;LERNER, RICHARD