发明名称 |
Codon optimised recombinant dermaphagoides allergens |
摘要 |
The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoids dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.
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申请公布号 |
US2003138441(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
US20020297563 |
申请日期 |
2002.12.09 |
申请人 |
BOLLEN ALEX;JACOBS PAUL;JACQUET ALAIN;MASSAER MARC GEORGES FRANCIS |
发明人 |
BOLLEN ALEX;JACOBS PAUL;JACQUET ALAIN;MASSAER MARC GEORGES FRANCIS |
分类号 |
C12N15/09;A61K38/00;A61K48/00;A61P11/06;A61P37/08;C07K14/435;C12N1/15;C12N1/19;C12N1/21;C12N5/10;(IPC1-7):A61K39/00;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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