发明名称 |
SIR2 PRODUCTS AND ACTIVITIES |
摘要 |
A novel compound, 2'/3'-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2' and 3' regioisomers of 0-acetyl-ADP ribose, and is formed nonenzymatically from 2'-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD<+>. Analogs of 2'/3'-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2'/3'-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2'/3'-O-acetyl-ADP-ribose are also provided. |
申请公布号 |
WO03045907(A3) |
申请公布日期 |
2003.07.17 |
申请号 |
WO2002US37364 |
申请日期 |
2002.11.21 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDECINE OF YESHIVA UNIVERSITY |
发明人 |
SCHRAMM, VERN, L.;BOEKE, JEF, D.;SUAVE, ANTHONY;CELIC, IVANA |
分类号 |
C12Q1/48;A61P35/00;C07H19/04;C07H19/20;C07H19/207;C12N9/10;C12N9/99;C12P19/32;C12P21/02 |
主分类号 |
C12Q1/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|