DISEASE MARKERS FOR RENAL DISEAES AND UTILIZATION THEREOF

摘要

Disease markers reflecting renal diseases accompanied by glomerular fibrosis; a method of detecting a renal disease accompanied by glomerular fibrosis using such a disease marker; and a method of screening a drug useful in ameliorating these disease. Namely, polynucleotides having at least 15 consecutive bases in the base sequence of ceramide glucosyltransferase (CGT) gene and/or polynucleotides complementary to these polynucleotides, etc. are used as disease markers for renal diseases accompanied by glomerular fibrosis. A drug for ameliorating renal diseases accompanied by glomerular fibrosis can be screened by bringing a test substance into contact with cells expressing the CGT gene and then examining the occurrence, increase or regulation of the expression of the CGT gene.