发明名称 Hyaluronidase preparation for ophtalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vitreous body of the eye
摘要 A thimerosal-free hyaluronidase preparation wherein the preferred hyaluronidase enzyme is devoid of molecular weight fractions below 4,000 MW, between 60-70,000 MW and above 100,000 MW. Also disclosed is a method for accelerating the clearance of hemorrhagic blood from the vitreous humor of the eye, said method comprising the step of contacting at least one hemorrhage-clearing enzyme (e.g., a beta-glucuronidase, matrix metalloproteinase, chondroitinase, chondroitin sulfatase or protein kinase) with the vitreous humor in an amount which is effective to cause accelerated clearance of blood therefrom.
申请公布号 US2003129182(A1) 申请公布日期 2003.07.10
申请号 US20030369372 申请日期 2003.02.14
申请人 KARAGEOZIAN HAMPAR L.;KARAGEOZIAN VICKEN H.;KENNEY MARIA CRISTINA;GUTIERREZ FLORES JOSE LUIS;CARPIO ARAGON GABRIEL ARTURO;NESBURN ANTHONY B. 发明人 KARAGEOZIAN HAMPAR L.;KARAGEOZIAN VICKEN H.;KENNEY MARIA CRISTINA;GUTIERREZ FLORES JOSE LUIS;CARPIO ARAGON GABRIEL ARTURO;NESBURN ANTHONY B.
分类号 A61K9/08;A61K31/00;A61K38/46;A61K38/47;A61K47/02;A61K47/26;A61P27/00;A61P27/02;(IPC1-7):A61K38/46;A61K38/43 主分类号 A61K9/08
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