发明名称 |
DOSAGE FORM FOR PROVIDING TIME-VARYING PATTERNS OF DRUG DELIVERY |
摘要 |
The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.
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申请公布号 |
WO03051341(A1) |
申请公布日期 |
2003.06.26 |
申请号 |
WO2002US40857 |
申请日期 |
2002.12.18 |
申请人 |
ALZA CORPORATION |
发明人 |
EDGREN, DAVID, EMIL;LI, SHU;WONG, PATRICK, S., L. |
分类号 |
A61K9/00;A61K9/22;A61K31/277;(IPC1-7):A61K9/28 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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